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Rotator cuff repair failure associated with family history

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Patients who receive surgical treatment for the shoulder injury known as rotator cuff tear may be more likely to have repair failures if there is a family history of rotator cuff tears.

A study published in the Journal of Shoulder and Elbow Surgery identified a familial and genetic predisposition for failure to heal following arthroscopic rotator cuff repair.

Researchers from the University of Utah recruited 72 patients undergoing arthroscopic repair for a full-thickness posterosuperior rotator cuff tear.

Magnetic resonance imaging (MRI) studies were performed at a minimum of one year postoperatively.

The researchers compared characteristics of cases with and without a family history of rotator cuff tearing. They also compared the frequency of single-nucleotide polymorphism 1758384 in oestrogen-related receptor beta (ESRRB) gene between patients who healed and those who failed to heal.

Among all participants, 42% of the rotator cuff repairs failed to heal and 42% of patients reported a family history of rotator cuff tear.

Results showed that there was a significant association between family history of rotator cuff tears and overall healing failure. The study also revealed a significant association between a single-nucleotide polymorphism variant in the ESRRB gene and lateral failures.

Meanwhile, a separate study published in the American Journal of Sports Medicine has looked at the rate of return to sport after treatment for rotator cuff tear.

Researchers examined 25 previous studies, including 859 patients. They found that most athletes (84.7%) treated surgically for rotator cuff tear returned to sport after 4-17 months, including almost two-thirds (65.9%) at an equivalent level of play, but only half (49.9%) of professional and competitive athletes return to an equivalent level of play.

http://www.healio.com/orthopedics/shoulder-elbow/news/online/ %7B18eb8065-bb03-48f8-bc75-bab92b24f311%7D/rotator-cuff-repair-failures-may-be-more-common-in-patients-with-a-family-history-of-tears

http://www.jshoulderelbow.org/article/S1058-2746 (16)00127-0/abstract