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Risk Of Fracture In Elderly Men Cut By Possible Drug Treatment

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Scientists from the University of Minnesota published a paper last month researching whether men aged between 65 and 100 and suffering from osteoporosis would benefit from a drug treatment to minimise the risk of fracture, the Health eGalaxy website reports.

The report, published in the British Medical Journal, looked at 5,880 patients; of this sample, 130 met the criteria of the the World Health Organisation (WHO) as suffering from osteoporosis, and 422 met the criteria of the National Osteoporosis Foundation (NOF). Another 936 men from the study were considered to be at a high risk of developing a fracture despite not having osteoporosis. This gave the study an osteoporosis prevalence of 9.4% and boosted the total prevalence of men suitable for drug treatment to 25.3%.

According to WHO criteria, the men with osteoporosis had a ten-year fracture risk of 20.6%, with NOF statistics standing at 6.8%; this gave the remaining patients in the study a 1.5% risk of developing a fracture.

Dr Kristine Ensrud, one of the researchers on the study, spoke to Reuters Health and noted that “the best strategy to identify men who are candidates for drug treatment to prevent fracture is uncertain”, as being able to identify osteoporosis from bone mineral density is “less well defined in men than in women.”

By including patients on the FRAX calculator (developed by WHO to evaluate patients´ fracture risk), the number of men eligible for drug treatment in the study rose significantly.

Dr Ensrud concluded that randomised, clinical trials should be undertaken in order to “establish the efficacy of treatment in reducing clinical fractures in older adults without osteoporosis, but at high fracture risk.”

http://www.hegalaxy.com/drug-treatment-could-cut-fracture-risk-in-elderly-men/ – KEEP

http://www.bmj.com/content/349/bmj.g4120 – KEEP